overview of Catharanthus roseus and medicinal properties of their metabolites against important diseases EUROPEAN ACADEMIC RESEARCH - Vol. The present review article concentrates chiefly on various biotechnological advancements based on plant tissue culture techniques of the last three decades, for instance, regeneration via direct and indirect organogenesis, somatic embryogenesis, secondary metabolite production, synthetic seed production, clonal fidelity assessment, polyploidization, genetic transformation, and nanotechnology. Periwinkle [Catharanthus roseus (L) G. Don] has become one of the very extensively investigated medicinal plants after the discovery of two powerful anti-cancer alkaloids, vinblastine and vincristine, in its leaves more than 50 years ago.These alkaloidal drugs are still in clinical use. Studies on animal models have shown that ethanolic extracts of the leaves and flowers of C. roseus lower blood glucose levels [55]. European herbalists used the plant for conditions as varied as headache to a folk remedy for diabetes. Cell line screening of Catharanthus roseus for high yield production of ajmalicine was conducted through subculturing of callus that induced from tetraploid plant leaves. edu (M. M.) Funding information Medical Research Foundation of Oregon; Research Startup Funds Abstract The medicinal plant Catharanthus roseus produces numerous secondary metabolites Catharanthus roseus (L.) G. Don, also known as Madagascar periwinkle or Sadabahar, is a herbaceous plant belonging to the family Apocynaceae. 0000069849 00000 n 0000080887 00000 n Periwinkle [Catharanthus roseus(L) G. Don] has become one of the very extensively investigated medicinal plants after the discovery of two powerful anti-cancer alkaloids, vinblastine and vincristine, in its leaves more than 50 years … Catharanthus roseus (C. roseus) is an important medicinal plant distributed in many countries. Research Article Catharanthus roseus Combined with Ursolic Acid Attenuates Streptozotocin-Induced Diabetes through Insulin Secretion and Glycogen Storage Huda Mohammed Alkreathy 1 and Aftab Ahmad 2 1Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia It is also commonly grown for its ornamental values and, due to ease of infection and distinctiveness of symptoms, is often used as the host for studies on phytoplasmas, an important group of uncultivated … Remarkably, vinblastine and vincristine isolated from this plant … 0000072477 00000 n 0000089069 00000 n 0000143872 00000 n Mukherjee E, Gantait S, Kundu S, Sarkar S, Bhattacharyya S. Appl Microbiol Biotechnol. The substrate was applied to image distribution of the metabolites in very fragile specimens such as the petal of Catharanthus roseus. 0000071505 00000 n • This review provides an insight on in vitro-based research achievements till date. 0000070087 00000 n Research article; Open Access; Published: 06 May 2016 Examining the transcriptional response of overexpressing anthranilate synthase in the hairy roots of an important medicinal plant Catharanthus roseus by RNA-seq. 0000074041 00000 n This site needs JavaScript to work properly. 2020 Oct 26;25(21):4945. doi: 10.3390/molecules25214945. • Key bottlenecks and prospective research methodologies have been identified herein. A white C. roseus flower Catharanthus roseus, commonly known as bright eyes, Cape periwinkle, graveyard plant, Madagascar periwinkle, old maid, pink periwinkle, rose periwinkle, is a species of flowering plant in the family Apocynaceae. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Endangered in the wild, it is a fast-growing plant that is easy to cultivate. The methanolic extracts also showed improvement in parameters like body weight and lipid profile as well as regeneration of -cells of pancreas in diabetic rats. 0000085276 00000 n Vinblastine and vincristine are two important anti-cancer drugs that are synthesized by the Terpenoid Indole Alkaloids (TIAs) pathway in periwinkle (Catharanthus roseus). The world's first comprehensive volume on Catharanthus roseus ; Includes research findings and review papers by world-renowned scientists from around the globe; Useful for a wide range of readers including plant scholars, scientists, researchers, graduate students, and botanists working on applications RESEARCH ARTICLE Open Access 1α, 25-dihydroxy Vitamin D3 containing fractions of Catharanthus roseus leaf aqueous extract inhibit preadipocyte differentiation and induce lipolysis in 3T3-L1 cells Anuj Kumar Borah1, Archana Singh1, Rafika Yasmin1, Robin Doley1, Venkata Satish Kumar Mattaparthi1 and We observed that the metabolites are distributed heterogeneously in the petal, which is consistent with previous results reported for the C. roseus … Catharanthus roseus cells suspended in production medium showed the presence of four Aspidosperma‐type alkaloids, however, no vindoline. 0000076142 00000 n 0000002696 00000 n 0000139800 00000 n Benyammi R, Paris C, Khelifi-Slaoui M, Zaoui D, Belabbassi O, Bakiri N, Meriem Aci M, Harfi B, Malik S, Makhzoum A, Desobry S, Khelifi L. Pharm Biol. 0000141673 00000 n Two of its alkaloids, vincristine and vinblastine (possessing anticancerous properties), are being used copiously in pharmaceutical industries. Abstract. 0000070560 00000 n ATP content increased in the leaves of C. roseus under UVB radiation. 0000070166 00000 n Identification of a low vindoline accumulating cultivar of Catharanthus roseus (L.) G. Don by alkaloid and enzymatic profiling. 2009 Apr;52(Pt 4):313-23. doi: 10.1042/BA20080239. Catharanthus roseus, commonly known as bright eyes, Cape periwinkle, graveyard plant, Madagascar periwinkle, old maid, pink periwinkle, rose periwinkle, is a species of flowering plant in the family Apocynaceae.It is native and endemic to Madagascar, but grown elsewhere as an ornamental and medicinal plant, a source of the drugs vincristine and vinblastine, used to treat cancer. Phytochemistry. 2019 Sep;103(18):7325-7354. doi: 10.1007/s00253-019-10035-6. The substrate was applied to image distribution of the metabolites in very fragile specimens such as the petal of Catharanthus roseus. 0000071189 00000 n The aim of this study was to extract and identify the major constituents, namely, the indole alkaloids, from two Apocynaceae medicinal plant family species, Catharanthus roseus and Vinca minor when using different solvents (the alcohol mixtures, the imidazolium-based ionic liquids (IL) and the novel choline- and menthol-based deep eutectic solvents (DESs)) in ultrasound-assisted processes. RESEARCH ARTICLES CURRENT SCIENCE, VOL. All groups were given a single dose of Streptozotocin (STZ) at a dose of 50 mg/kg by intraperitoneal route for induction of diabetes, except the normal control group. 0000095484 00000 n Catharanthus roseus is the sole commercial source of the monoterpenoid indole alkaloids (MIAs), vindoline and catharanthine, components of the commercially important anticancer dimers, vinblastine and vincristine. International Journal of Crude Drug Research: Vol. Rats were divided into six groups. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Catharanthus roseus belonging to family Apocynaceae is a plant with high medicinal importance and wide occurrence all over the world. 0000143590 00000 n 0000080814 00000 n 0000142557 00000 n It is known for its antitumour, anti-diabetic, anti-microbial, anti-oxidant and anti-mutagenic effects. Physicochemical characterization was performed by Expasy’s Protparam server. 0000080634 00000 n 0000070324 00000 n Catharanthus roseus belonging to family Apocynaceae is a plant with high medicinal importance and wide occurrence all over the world. 0000069530 00000 n 26, No. Anticancerous; Genetic transformation; Nanotechnology; Polyploidy; Secondary metabolite; Somatic embryogenesis. 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